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      Acute Effects of Transdermal Estrogen in Postmenopausal Women with Coronary Artery Disease

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          Abstract

          In the present study the acute anti-ischemic effect of clinically relevant doses of transdermal estradiol during concurrent antianginal therapy was investigated in 14 postmenopausal women with stable coronary artery disease. Plasma estradiol was significantly increased, but no significant effects on time to angina, time to 1 mm S–T depression, total exercise time, maximum rate-pressure product, maximum S–T depression or maximum workload were found. However, resting diastolic blood pressure was significantly decreased due to estrogen.

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          Most cited references 3

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          The inhibition of low-density lipoprotein oxidation by 17-β estradiol

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            Hormone replacement therapy and serum angiotensin-converting-enzyme activity in postmenopausal women

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              Does sublingual 17β-oestradiol have any effects on exercise capacity and myocardial ischaemia in post-menopausal women with stable coronary artery disease?

               F Al-Khalili (1998)
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                Author and article information

                Journal
                CRD
                Cardiology
                10.1159/issn.0008-6312
                Cardiology
                S. Karger AG
                0008-6312
                1421-9751
                2000
                January 2001
                12 January 2001
                : 94
                : 2
                : 86-90
                Affiliations
                aClinical-Experimental Research Laboratory, Department of Medicine, and bDepartment of Obstetrics and Gynecology, Sahlgrenska University Hospital/Östra, Göteborg University, Göteborg, Sweden
                Article
                47297 Cardiology 2000;94:86–90
                10.1159/000047297
                11173778
                © 2001 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Tables: 1, References: 31, Pages: 5
                Categories
                General Cardiology

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