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      Functional changes in brain activity during priming in Alzheimer's disease.

      1 , , ,
      Journal of cognitive neuroscience

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          Abstract

          Patients with Alzheimer's disease (AD) are often impaired on certain forms of implicit memory, such as word-stem completion priming (WSCP). Lesion data suggest that deficient WSCP may be associated with abnormal functioning in the posterior neocortex. Using positron emission tomography (PET), we here provide direct support for this view. Compared with normal old adults, AD patients showed reduced priming on a word-stem completion task. The normal old showed decreased activity in right occipital cortex (area 19), whereas the AD patients showed increased activity in this region during priming. To the extent that decreased activity during priming reflects an experience-dependent reduction of the neuronal population involved, these results indicate that shaping of the relevant neurons is slower in AD, possibly as a result of inadequate initial stimulus-processing.

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          Author and article information

          Journal
          J Cogn Neurosci
          Journal of cognitive neuroscience
          0898-929X
          0898-929X
          Jan 2000
          : 12
          : 1
          Affiliations
          [1 ] Uppsala University, Stockholm Gerontology Research Center, and Karolinska Institute, Sweden.
          Article
          10769311
          fc8d27dc-d981-4c50-b2ab-16b785215d10
          History

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