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      Effect of Thrombin on Isolated Canine Blood Vessels


      Journal of Vascular Research

      S. Karger AG

      Thrombin, Vasodilatation, Vasoconstriction, Proteolytic activity

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          The aim of the present study was to assess whether or not thrombin affects vascular smooth muscle activity by a direct action on the blood vessel wall. In isolated saphenous veins and femoral and pulmonary arteries thrombin did not affect basal tension, but in pulmonary and portal mesenteric veins it caused contraction. In saphenous and femoral veins and in femoral and pulmonary arteries the enzyme depressed contractions evoked by α-adrenergic stimulation. In the saphenous vein thrombin also depressed contractions induced with acetylcholine or potassium ions. In this blood vessel the relaxation caused by thrombin was abolished by antithrombin III and the tripeptide D-phenylalanine-proline-arginine-CH<sub>2</sub>Cl, a specific inhibitor of the enzymatic center of thrombin. In pulmonary and portal mesenteric veins, thrombin potentiated the contractile response to norepinephrine. These contractile effects of thrombin were also abolished by D-phenylalanine-proline-arginine-CH<sub>2</sub>Cl. Thus, thrombin causes relaxation or contraction of blood vessels through a direct action on the blood vessel wall. These effects are due to its proteolytic activity.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          19 September 2008
          : 19
          : 3
          : 126-134
          Center for Thrombosis and Vascular Research, Catholic University of Leuven, Belgium
          158379 Blood Vessels 1982;19:126–134
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 9
          Research Paper


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