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      Demonstration of viraemia patterns in haemophiliacs treated with hepatitis-C-virus-contaminated factor VIII concentrates.

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          Abstract

          Sequential serum samples from previously untreated haemophiliacs in whom non-A, non-B hepatitis (NANBH) developed after they received factor VIII concentrate contaminated with hepatitis C virus (HCV) were tested by a commercial assay for the presence of antibodies to the C100 protein of HCV (anti-C100) and by "nested" PCR for the presence of HCV RNA sequences. Three temporal patterns of viraemia were observed: transient viraemia in acute resolving NANBH; viraemia lasting for several years in chronic NANBH; and intermittent viraemia in chronic NANBH, with an initial transient phase followed by recurrence after many months. In three of five cases the initial detection of serum HCV RNA was made before the onset of liver function test abnormality, many weeks or months before anti-C100 seroconversion. Diagnosis of acute HCV infection may therefore be possible much earlier by PCR than by existing serological techniques, but the timing of samples may be critical.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          0140-6736
          0140-6736
          Oct 27 1990
          : 336
          : 8722
          Affiliations
          [1 ] Department of Medical Microbiology, University College and Middlesex School of Medicine, London, UK.
          Article
          0140-6736(90)92487-3
          1977017
          fcafc3a3-3546-4dc0-9532-3324e6d2f888
          History

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