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      Familial Salivary Gland Insensitivity to Aldosterone: A Variant of Pseudohypoaldosteronism

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          Abstract

          Two male siblings presented in infancy with hyponatraemia. Levels of plasma renm activity and aldosterone were elevated. Sodium supplementation was necessary to maintain normal sodium balance. Urinary sodium concentration and renal epithelial exchange between sodium and potassium were normal; however, salivary sodium concentrations were markedly elevated with sweat sodium levels being in the upper normal range. Excess salivary sodium loss accounted for sodium depletion in these cases who present a new variant of pseudohypoaldosteronism associated with normal renal sodium transport.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1989
          1989
          02 December 2008
          : 32
          : 4
          : 145-147
          Affiliations
          Queen Elizabeth Hospital for Children, London, UK
          Article
          181277 Horm Res 1989;32:145–147
          10.1159/000181277
          2625324
          © 1989 S. Karger AG, Basel

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          Pages: 3
          Categories
          Original Paper

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