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      NRF2 and the Hallmarks of Cancer

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      Cancer Cell
      Elsevier BV

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          Abstract

          The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy. Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor-promoting effects.

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          Author and article information

          Journal
          Cancer Cell
          Cancer Cell
          Elsevier BV
          15356108
          July 2018
          July 2018
          : 34
          : 1
          : 21-43
          Article
          10.1016/j.ccell.2018.03.022
          6039250
          29731393
          fcd52c63-08f8-44e5-b616-02110daae56a
          © 2018

          https://www.elsevier.com/tdm/userlicense/1.0/

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