5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Development and characterization of poly(lactic-co-glycolic) acid nanoparticles loaded with copaiba oleoresin.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Copaiba oleoresin (CPO), obtained from Copaifera landgroffii, is described as active to a large number of diseases and more recently in the endometriosis treatment. In this work, poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing CPO were obtained using the design of experiments (DOE) as a tool to optimize the production process. The nanoparticles optimized by means of DOE presented an activity in relation to the cellular viability of endometrial cells. The DOE showed that higher amounts of CPO combined with higher surfactant concentrations resulted in better encapsulation efficiency and size distribution along with good stability after freeze drying. The encapsulation efficiency was over 80% for all produced nanoparticles, which also presented sizes below 300 nm and spherical shape. A decrease in viability of endometrial stromal cells from ectopic endometrium of patients with endometriosis and from eutopic endometriotic lesions was demonstrated after 48 h of incubation with the CPO nanoparticles. The nanoparticles without CPO were not able to alter the cell viability of the same cells, indicating that this material was not cytotoxic to the tested cells and suggesting that the effect was specific to CPO. The results indicate that the use of CPO nanoparticles may represent a promising alternative for the treatment of endometriosis.

          Related collections

          Author and article information

          Journal
          Pharm Dev Technol
          Pharmaceutical development and technology
          Informa UK Limited
          1097-9867
          1083-7450
          Apr 2018
          : 23
          : 4
          Affiliations
          [1 ] a Department of Pharmaceutics , Federal University of Rio de Janeiro , Rio de Janeiro , Brazil.
          [2 ] b Research Program in Cellular Biology and Development, Institute of Biomedical Sciences, Federal University of Rio de Janeiro , Rio de Janeiro , Brazil.
          [3 ] c School of Pharmacy, Trinity College, University of Dublin , Dublin , Ireland.
          Article
          10.1080/10837450.2017.1290107
          28145793
          fce6c2b5-33d2-4893-9f29-3fa0d7e9901d

          Comments

          Comment on this article