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      Predictors of poor outcome and benefits from antibiotics in children with acute otitis media: pragmatic randomised trial.

      BMJ : British Medical Journal
      Acute Disease, Anti-Bacterial Agents, therapeutic use, Child, Child, Preschool, Cough, etiology, Fever, Humans, Infant, Otitis Media, complications, drug therapy, Patient Selection, Primary Health Care, methods, Prognosis, Treatment Outcome, Vomiting

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          Abstract

          To identify which children with acute otitis media are at risk of poor outcome and to assess benefit from antibiotics in these children. Secondary analysis of randomised controlled trial cohort. Primary care. 315 children aged 6 months to 10 years. Immediate or delayed (taken after 72 hours if necessary) antibiotics. Predictors of short term outcome: an episode of distress or night disturbance three days after child saw doctor. Distress by day three was more likely in children with high temperature (adjusted odds ratio 4.5, 95% confidence interval 2.3 to 9.0), vomiting (2.6,1.3 to 5.0), and cough (2.0, 1.1 to 3.8) on day one. Night disturbance by day three was more likely with high temperature 2.4 (1.2 to 4.8), vomiting (2.1,1.1 to 4.0), cough (2.3,1.3 to 4.2), and ear discharge (2.1, 1.2 to 3.9). Among the children with high temperature or vomiting, distress by day three was less likely with immediate antibiotics (32% for immediate v 53% for delayed, chi2=4.0; P=0.045, number needed to treat 5) as was night disturbance (26% v 59%, chi2=9.3; P=0.002; number needed to treat 3). In children without higher temperature or vomiting, immediate antibiotics made little difference to distress by day three (15% v 19%, chi2=0.74; P=0.39) or night disturbance (20% v 27%, chi2=1.6; P=0.20). Addition of cough did not significantly improve prediction of benefit. In children with otitis media but without fever and vomiting antibiotic treatment has little benefit and a poor outcome is unlikely.

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