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      Growth Hormone, Insulin-Like Growth Factor-I and Lipid Metabolism: Interactions with Sex Steroids

      Hormone Research in Paediatrics

      S. Karger AG

      Growth hormone, Testosterone, Estrogen, Progesterone, Adipose tissue, Cortisol

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          Abstract

          Steroid hormones usually act via specific receptors and the hormone-receptor complex then influences the transcription of genes. These effects are often permissive for the actions of peptide hormones such as insulin and growth hormone (GH). The best known effects are those of cortisol. Since cortisol is always present, the sex steroids often modify cortisol effects. In adipose tissue, lipoprotein lipase (LPL), in the presence of insulin, is expressed via a glucocorticoid receptor, increasing transcription and stabilizing the enzyme. This process is efficiently inhibited by GH via posttranslational effects, and lipolysis is markedly stimulated. Testosterone inhibits LPL expression and, in the presence of GH, markedly increases lipolysis via multiple interactions along the lipolytic cascade. In human adipose tissue, direct effects of estrogen and progesterone cannot be demonstrated, probably because of the apparent absence of specific receptors. These hormones presumably via indirect mechanisms, perhaps by interaction with other hormone receptors.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-6432-8
          978-3-318-00112-9
          1663-2818
          1663-2826
          1996
          1996
          09 December 2008
          : 46
          : 4-5
          : 188-191
          Affiliations
          Department of Heart and Lung Diseases, Sahlgren’s Hospital, University of Göteborg, Sweden
          Article
          185021 Horm Res 1996;46:188–191
          10.1159/000185021
          8950619
          © 1996 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Session 2: GH, IGF-I and Metabolism

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