Etymologically derived from the Greek word semeion which means ‘sign,’ semiotics can be defined as the study of signs and of the systems, rules and conventions that allow signs to have meaning. This thematic issue of Cultura Journal seeks to provide an overview of different theories on the study of sign systems and their impact upon social practices across the world. In order to achieve this goal, the volume incorporates papers that deal with ancient civilizations and contemporary societies, ways of thinking and experiences from a broad spectrum of world cultures. Interestingly, the impact of Western semiotics is strongly felt upon the non Western analyses that form part of this issue. Many studies take as starting point the work of the North-American pragmatist Charles Sanders Peirce; others focus on the ideas developed by European linguists such as Ferdinand de Saussure, C.K. Ogden and I.A. Richards, or Roland Barthes. Undoubtedly, this shows the impact of critical theory on knowledge development and dissemination. But even more importantly, it illustrates the uneven distribution, and unfair location of knowledge production in certain economic clusters and regions of the world, disclosing the mechanisms that enable the empowerment of certain cultures at the expense of others.