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      Metabolic profiling in human lung injuries by high-resolution nuclear magnetic resonance spectroscopy of bronchoalveolar lavage fluid (BALF)

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          An expanded definition of the adult respiratory distress syndrome.

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            Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism.

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              Metabolomics: a global biochemical approach to drug response and disease.

              Metabolomics is the study of metabolism at the global level. This rapidly developing new discipline has important potential implications for pharmacologic science. The concept that metabolic state is representative of the overall physiologic status of the organism lies at the heart of metabolomics. Metabolomic studies capture global biochemical events by assaying thousands of small molecules in cells, tissues, organs, or biological fluids-followed by the application of informatic techniques to define metabolomic signatures. Metabolomic studies can lead to enhanced understanding of disease mechanisms and to new diagnostic markers as well as enhanced understanding of mechanisms for drug or xenobiotic effect and increased ability to predict individual variation in drug response phenotypes (pharmacometabolomics). This review outlines the conceptual basis for metabolomics as well as analytical and informatic techniques used to study the metabolome and to define metabolomic signatures. It also highlights potential metabolomic applications to pharmacology and clinical pharmacology.
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                Author and article information

                Journal
                Metabolomics
                Metabolomics
                Springer Nature
                1573-3882
                1573-3890
                June 2013
                October 16 2012
                June 2013
                : 9
                : 3
                : 667-676
                Article
                10.1007/s11306-012-0472-y
                fd36a228-6f83-4e07-a092-370b0b058ece
                © 2013
                History

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