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Impact of inactivated extracellular proteases on the modified flagellin type III secretion pathway of Bacillus halodurans.

Author(s): Susan Gerber, E N Nxumalo, Michael Crampton, E. Du, Maureen Louw, Eldie Berger

Publication date: 2008-12-31

Journal: Applied and Environmental Microbiology

Keywords: Bacillus, metabolism, Bacterial Proteins, genetics, Flagellin, Gene Deletion, Membrane Transport Proteins, Peptide Hydrolases, Recombinant Fusion Proteins

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Abstract

The flagellin type III secretion pathway of Bacillus halodurans BhFC01 (Deltahag) was modified by the inactivation of fliD. An in-frame flagellin gene fusion polypeptide construct was expressed, and the heterologous peptides were secreted as flagellin fusion monomers. The stability of the secreted monomers was significantly enhanced through gene-targeted inactivation of extracellular proteases.

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PubMed ID:: 18997028

PMC ID:: 2612215

DOI:: 10.1128/AEM.02430-08

ScienceOpen disciplines: Chemistry

Keywords: Bacillus,metabolism,Bacterial Proteins,genetics,Flagellin,Gene Deletion,Membrane Transport Proteins,Peptide Hydrolases,Recombinant Fusion Proteins

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ScienceOpen disciplines: Chemistry

Keywords: Bacillus, metabolism, Bacterial Proteins, genetics, Flagellin, Gene Deletion, Membrane Transport Proteins, Peptide Hydrolases, Recombinant Fusion Proteins

Impact of inactivated extracellular proteases on the modified flagellin type III secretion pathway of Bacillus halodurans.

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