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      COVID-19 vaccines: challenges and promises of trials, manufacturing and allocation of doses

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          Reflections on challenges and promises of COVID-19 vaccine development show opportunities for innovation and collaboration between stakeholders.

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          Interpreting a covid-19 test result

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            A strategic approach to COVID-19 vaccine R&D

            A public-private partnership and platform for harmonized clinical trials aims to accelerate licensure and distribution.
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              Challenges in Laboratory Diagnosis of the Novel Coronavirus SARS-CoV-2

              The recent outbreak of the Coronavirus disease 2019 (COVID-19) has quickly spread worldwide since its discovery in Wuhan city, China in December 2019. A comprehensive strategy, including surveillance, diagnostics, research, clinical treatment, and development of vaccines, is urgently needed to win the battle against COVID-19. The past three unprecedented outbreaks of emerging human coronavirus infections at the beginning of the 21st century have highlighted the importance of readily available, accurate, and rapid diagnostic technologies to contain emerging and re-emerging pandemics. Real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) based assays performed on respiratory specimens remain the gold standard for COVID-19 diagnostics. However, point-of-care technologies and serologic immunoassays are rapidly emerging with high sensitivity and specificity as well. Even though excellent techniques are available for the diagnosis of symptomatic patients with COVID-19 in well-equipped laboratories; critical gaps still remain in screening asymptomatic people who are in the incubation phase of the virus, as well as in the accurate determination of live viral shedding during convalescence to inform decisions for ending isolation. This review article aims to discuss the currently available laboratory methods and surveillance technologies available for the detection of COVID-19, their performance characteristics and highlight the gaps in current diagnostic capacity, and finally, propose potential solutions. We also summarize the specifications of the majority of the available commercial kits (PCR, EIA, and POC) for laboratory diagnosis of COVID-19.
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                Author and article information

                Journal
                Future Drug Discov
                Future Drug Discov
                FDD
                Future Drug Discovery
                Newlands Press Ltd (London, UK )
                2631-3316
                15 December 2020
                November 2020
                15 December 2020
                Affiliations
                1MPhil in Therapeutic Sciences, Cambridge Academy of Therapeutic Sciences, University of Cambridge, Cambridge CB2 1RX, UK
                Author notes
                [* ]Author for correspondence: bs583@ 123456cam.ac.uk
                Article
                10.4155/fdd-2020-0031
                7737565
                © 2020 Benedetta Spadaro

                This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License

                Page count
                Pages: 4
                Product
                Categories
                Editorial

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