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      Effect of Ovariectomy and Estradiol Benzoate Treatment on LH-RH Induced LH and FSH Release in the Female Rabbit

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          Abstract

          Synthetic LH-RH (0.75 and 2.5 µg/animal) was administered to mature intact and castrated female rabbits. The animals were injected for 3 consecutive days with either 40 µg estradiol benzoate (EB) dissolved in 0.5 ml propylene glycol 60 %, water 40 % or with the solvent alone. LH-RH was injected i.v. on the 4th day. In intact rabbits EB priming increased the pituitary LH response while LH basal levels were lowered. In the unprimed castrated rabbits, basal FSH and LH levels and the cumulative responses to LH-RH were higher than in intact control animals; EB priming lowered basal LH levels and cumulative responses to the values of intact control rabbits while both basal FSH levels and the cumulative responses were less influenced by the treatment. It is concluded that estrogen acts at both hypothalamic and pituitary levels to modify the LH responses to endogenous LH-RH, and that the complete inhibition of FSH hypersecretion in the ovariectomized rabbit probably needs another ovarian factor.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1975
          1975
          21 November 2008
          : 6
          : 5-6
          : 372-379
          Affiliations
          Laboratoire de Neurophysiologie, Université de Bordeaux II, Bordeaux, and Laboratoire de Radio-immunologie, Université de Liège, Liège
          Article
          178688 Horm Res 1975;6:372–379
          10.1159/000178688
          780249
          © 1975 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Original Paper

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