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      Periodontitis as a risk factor for systemic disease: Are microparticles the missing link?

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          Abstract

          Periodontitis is an oral inflammatory disease affecting the teeth supportive tissue. Its bacterial infectious etiology is well established. Periodontitis has been associated with increased prevalence of systemic diseases such as cardiovascular diseases, diabetes, rheumatoid arthritis, preeclampsia, preterm birth and inflammatory bowel disease. The rational of considering periodontitis as risk factor for systemic disease is the passage of inflammatory cytokines and/or bacteria in the bloodstream, thus affecting distant organs. Membrane microparticles are released by multiple cells in inflammatory environment. Recent data suggested the role of these microparticles in the pathogenic process of many systemic diseases, that can be also associated to periodontitis. We hypothesized that periodontitis could be a chronic reservoir of microparticles, hence elucidating partially the interaction with systemic diseases initiation or progression.

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          Author and article information

          Journal
          Med. Hypotheses
          Medical hypotheses
          1532-2777
          0306-9877
          Jun 2015
          : 84
          : 6
          Affiliations
          [1 ] Department of Periodontology (UIC Odontology, CHU, LIOAD Inserm U791), Faculty of Dental Surgery, University of Nantes, France.
          [2 ] LIOAD, Inserm U791, Faculty of Dental Surgery, University of Nantes, France.
          [3 ] INSERM, U1063, University of Angers, France.
          [4 ] Department of Periodontology (UIC Odontology, CHU, LIOAD Inserm U791), Faculty of Dental Surgery, University of Nantes, France. Electronic address: assem.soueidan@univ-nantes.fr.
          Article
          S0306-9877(15)00090-0
          10.1016/j.mehy.2015.02.013
          25749377
          fd4b9137-ba0a-49f3-ad59-f60e13255691
          Copyright © 2015 Elsevier Ltd. All rights reserved.
          History

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