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      Preparation and Oral Bioavailability Study of Curcuminoid-Loaded Microemulsion

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          Abstract

          Curcuminoid, a dietary polyphenolic compound, has poor water solubility and low bioavailability following oral administration. The aim of this study was to develop a formulation of curcuminoid-loaded microemulsion (Cur-ME) to improve its oral bioavailability. The optimized Cur-ME formulation was prepared by using labrafac lipophile WL 1349, cremophor RH 40, and glycerine as the oil phase, the surfactant, and the cosurfactant, respectively. Pharmacokinetics and bioavailability of curcuminoid suspension and Cur-ME were evaluated and compared in rats. Plasma bisdemethoxycurcumin (BDMC), treated as the representing component of curcuminoid, was determined by high-performance liquid chromatography with fluorescence detector. After gavage administration of curcuminoid suspension, the plasma BDMC level was very low, below 5 ng/mL, whereas for Cur-ME, double peak of maximum concentrations were observed. The relative bioavailability of Cur-ME was enhanced in an average of 9.6-fold that of curcuminoid suspension. It was concluded that the bioavailbility of curcuminoid was enhanced greatly by the microemulsion.

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          Author and article information

          Journal
          Journal of Agricultural and Food Chemistry
          J. Agric. Food Chem.
          American Chemical Society (ACS)
          0021-8561
          1520-5118
          April 03 2013
          April 17 2013
          April 03 2013
          April 17 2013
          : 61
          : 15
          : 3654-3660
          Affiliations
          [1 ]Department of Pharmaceutics, Key Lab of State Natural Medicine, China Pharmaceutical University, Nanjing 210009, China
          [2 ]The Affiliated Hospital of Jiangxi College of Traditional Chinese Medicine, Nanchang 330006, China
          Article
          10.1021/jf400002x
          23451842
          fd5da84b-562d-42af-a4a6-74e14f729087
          © 2013
          History

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