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      Fractional Oxalate Clearance in Subjects with Normal and Impaired Renal Function

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          Abstract

          The <sup>14</sup>C-oxalate clearance was determined in 13 healthy subjects and 22 patients with various diseases and varying degrees of renal functional impairment, including 5 patients with primary hyperoxaluria (PH). The clearances of oxalate (C<sub>ox</sub>) and creatinine (C<sub>cr</sub>) were correlated (r = 0.95). The regression line intersects the ordinate at the origin, while the regression coefficient is 2.0. This implies that the fractional C<sub>ox</sub> is constant, irrespective of the underlying disease and the degree of renal failure. Plasma oxalate (P<sub>ox</sub>), as calculated from the urinary oxalate excretion (U<sub>ox</sub>) and C<sub>ox</sub>, was elevated in patients with severely impaired kidney function and those with PH. Plasma creatinine (P<sub>cr</sub>) and P<sub>ox</sub> were correlated as well (r = 0.83). P<sub>ox</sub> values of patients with PH were above the 95% confidence limits of the regression line. It is of practical importance that Pox can be estimated from U<sub>ox</sub> and C<sub>cr</sub> when a <sup>14</sup>C-oxalate clearance test cannot be performed. The reasons for the constancy of the C<sub>ox</sub>/C<sub>cr</sub> ratio are discussed, and it is suggested that the effective renal plasma flow (ERPF) is the regulating factor for the tubular secretion of oxalate.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1985
          1985
          04 December 2008
          : 41
          : 1
          : 78-81
          Affiliations
          Department of Nephrology and Hypertension, University Hospital, Utrecht, The Netherlands
          Article
          183551 Nephron 1985;41:78–81
          10.1159/000183551
          4033845
          fd62fbde-6d1b-43c6-a4b1-3344f53a4aba
          © 1985 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 20 November 1984
          Page count
          Pages: 4
          Categories
          Original Paper

          Cardiovascular Medicine,Nephrology
          Primary hyperoxaluria, 14C-oxalate,Oxalate clearance,Plasma oxalate,Urinary oxalate,Creatinine clearance,Plasma creatinine,Kidney diseases,Hyperoxaluria

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