A Novel Link between Inflammation and Cancer.

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Abstract

Immune checkpoint-blockade treatments targeting PD-1/PD-L1 have revolutionized cancer therapy. Hence, understanding the regulation of PD-L1 expression has major clinical relevance. In this issue of Cancer Cell, Lim et al. report that inflammation-induced and NF-κB-driven expression of deubiquitinating enzyme CSN5 leads to PD-L1 stabilization and immune suppression in tumors.

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Journal

Journal ID (iso-abbrev): Cancer Cell

Title: Cancer cell

Publisher: Elsevier BV

ISSN (Electronic): 1878-3686

ISSN (Print): 1535-6108

Publication date (Electronic): Dec 12 2016

Volume: 30

Issue: 6

Affiliations

[1 ] Department of Microbiology & Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

[2 ] Department of Microbiology & Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: sg2715@cumc.columbia.edu.

Article

Publisher Item ID: S1535-6108(16)30556-6

DOI: 10.1016/j.ccell.2016.11.013

PubMed ID: 27960080

SO-VID: fd63d541-2d70-4ff1-972d-a3277c9b775e

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