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      Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*

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          Abstract

          Critical Care Medicine, 34(6), 1589-1596

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          Quality of care, process, and outcomes in elderly patients with pneumonia.

          Pneumonia is a frequent cause of hospitalization and death among elderly patients, but the relationships between processes of care for pneumonia and outcomes are uncertain, making quality improvement a challenge. To assess quality of care for Medicare patients hospitalized with pneumonia and to determine whether process of care performance is associated with lower 30-day mortality. Multicenter retrospective cohort study with medical record review. A total of 3555 acute care hospitals throughout the United States. A total of 14069 patients at least 65 years old hospitalized with pneumonia. Four processes of care: time from hospital arrival to initial antibiotic administration; blood culture collection before initial hospital antibiotics; blood culture collection within 24 hours of hospital arrival; and oxygenation assessment within 24 hours of hospital arrival. Associations between processes of care and 30-day mortality were determined with logistic regression analysis. National estimates of process-of-care performance were antibiotic administration within 8 hours of hospital arrival, 75.5% (95% confidence interval [CI], 73.1-77.9); blood cultures before antibiotics, 57.3% (95% CI, 54.5-60.1); initial blood culture collection, 68.7% (95% CI, 66.2-71.2); and initial oxygenation assessment, 89.3% (95% CI, 87.5-90.9). Lower 30-day mortality was associated with antibiotic administration within 8 hours of hospital arrival (odds ratio [OR], 0.85; 95% CI, 0.75-0.96) and blood culture collection within 24 hours of arrival (OR, 0.90; 95% CI, 0.81-1.00). State and territory performance estimates varied from 49.0% to 89.7% for antibiotics given within 8 hours and from 45.6% to 82.6% for blood cultures drawn within 24 hours. Administering antibiotics within 8 hours of hospital arrival and collecting blood cultures within 24 hours were associated with improved survival. The fact that states varied widely in the performance of these measures suggests that opportunities exist to improve hospital care of elderly patients with pneumonia.
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            Author and article information

            Journal
            Ovid Technologies (Wolters Kluwer Health)
            2006
            June 2006
            18 April 2019
            Article
            10.1097/01.CCM.0000217961.75225.E9
            16625125
            fd66589b-bd4b-43c4-8623-538859f00130
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