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      Cooling Augments Contractile Response to 5-Hydroxytryptamine via an Endothelium-Dependent Mechanism

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          Abstract

          The interaction between cooling and vasoactive substances, e.g. 5-hydroxytryptamine (5-HT), plays an important role in the pathophysiology of cold-induced vasospasm. Our objective was to study the effect of cooling on the 5-HT vascular response, classify the involved 5-HT receptors, and to analyze the role of the endothelium. Ring segments from the rat jugular vein, a preparation without α-adrenergic receptors, were suspended in organ baths to record the circular motor activity. The temperature was initially 37 °C and was thereafter either continuously lowered to 10 °C or kept constant at different temperatures within this range. 5-HT at low concentrations (10<sup>–11</sup> to 3 × 10<sup>–8</sup> M) induced relaxation at 37 °C in segments precontracted by prostaglandin F<sub>2α</sub><sup>–</sup> The relaxation was recognized to be mediated via an endothelium-dependent 5-HT<sub>1</sub>-like receptor mechanism presumably involving the release of endothelium-derived relaxing factor (EDRF). Cooling to 29 and 20 °C diminished the relaxation, probably due to an attenuated release of EDRF. 5-HT at concentrations of more than 10<sup>–8</sup> M induced a contraction in all vessels at 37 °C mediated via a 5-HT<sub>2 </sub>receptor. An increased 5-HT-induced contraction was seen at temperatures below 37 °C in vessels with an intact endothelium. Endothelial denudation diminished the cold-induced enhancement of the contraction to 5-HT. These studies suggest that endothelial mechanisms contribute to a cold-induced augmented response to 5-HT.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1989
          1989
          23 September 2008
          : 26
          : 6
          : 347-359
          Affiliations
          Departments of aSurgery and bAnesthesiology, Lund University, Lund, Sweden
          Article
          158785 Blood Vessels 1989;26:347–359
          10.1159/000158785
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 13
          Categories
          Research Paper

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