10
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The colonic microflora and probiotic therapy in health and disease.

      Current Opinion in Gastroenterology
      Colon, microbiology, Colonic Diseases, therapy, Humans, Probiotics, therapeutic use

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Host-microbe dialogue is involved not only in maintenance of mucosal homeostasis but also in the pathogenesis of several infectious, inflammatory, and neoplastic disorders of the gut. This has led to a resurgence of interest in the colonic microbiota in health and disease. Recent landmark findings are addressed here. Reciprocal signalling between the immune system and the microbiota plays a pivotal role in linking alterations in gut microbiota with risk of metabolic disease in the host, notably insulin resistance, obesity, and chronic low-grade inflammation. Loss of ancestral indigenous organisms consequent upon a modern lifestyle may contribute to an increased frequency of various metabolic and immuno-allergic diseases. The potential to address this underpins the science of pharmabiotics. Advances in understanding host-microbe interactions within the gut can inform rational probiotic or pharmabiotic selection criteria. In addition, the gut microbiota may be a repository for drug discovery as well as a therapeutic target.

          Related collections

          Author and article information

          Journal
          20885319
          10.1097/MOG.0b013e328340076f

          Chemistry
          Colon,microbiology,Colonic Diseases,therapy,Humans,Probiotics,therapeutic use
          Chemistry
          Colon, microbiology, Colonic Diseases, therapy, Humans, Probiotics, therapeutic use

          Comments

          Comment on this article