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      Increased leukocyte mitochondrial DNA copy number is associated with oral premalignant lesions: an epidemiology study.

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          Abstract

          Although changes in the mitochondrial DNA (mtDNA) copy number in peripheral blood leukocytes (PBLs) have been linked to increased susceptibility to several cancers, the relationship between the mtDNA copy number in PBLs and the risk of cancer precursors has not been investigated. In this study, we measured the relative mtDNA copy number in PBLs of 143 patients with histologically confirmed oral premalignant lesions (OPLs) and of 357 healthy controls that were frequency-matched to patients according to age, sex and race. OPL patients had a significantly higher mtDNA copy number than the controls (1.36 ± 0.74 versus 1.11 ± 0.32; P < 0.001). In analyses stratified by sex, race, alcohol consumption and smoking status, the mtDNA copy number was higher in the OPL patients than in the controls in all the strata. Using the median mtDNA copy number in the control group as a cutoff, we found that individuals with a high mtDNA copy number had significantly higher risk of having OPLs than individuals with a low mtDNA copy number (adjusted odds ratio, 1.93; 95% confidence interval, 1.23-3.05, P = 0.004). Analysis of the joint effect of alcohol consumption and smoking revealed even greater risk for OPLs. Our results suggest that high mtDNA copy number in PBLs is significantly associated with having OPLs. To our knowledge, this is the first epidemiologic study to show that the mtDNA copy number may indicate the risk of cancer precursors.

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          Author and article information

          Journal
          Carcinogenesis
          Carcinogenesis
          Oxford University Press (OUP)
          1460-2180
          0143-3334
          Aug 2014
          : 35
          : 8
          Affiliations
          [1 ] Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA, Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
          [2 ] Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
          [3 ] Department of Biostatistics, The University of Texas MD Anderson Center, Houston, TX 77030, USA and.
          [4 ] Moores Cancer Center, University of California San Diego, San Diego, CA 92093, USA.
          [5 ] Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA, xwu@mdanderson.org.
          Article
          bgu093
          10.1093/carcin/bgu093
          4123647
          24743515

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