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The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine.

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IUBMB life

Wiley-Blackwell

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      Abstract

      The glycerophospholipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE) account for greater than 50% of the total phospholipid species in eukaryotic membranes and thus play major roles in the structure and function of those membranes. In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn-1,2-diradylglycerol and either CDP-choline or CDP-ethanolamine, respectively. This is the last step in a biosynthetic pathway known as the Kennedy pathway, so named after Eugene Kennedy who elucidated it over 50 years ago. This review will cover various aspects of the Kennedy pathway including: each of the biosynthetic steps, the functions and roles of the phospholipid products PC and PE, and how the Kennedy pathway has the potential of being a chemotherapeutic target against cancer and various infectious diseases.

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      Affiliations
      [1 ] Centre for Biomolecular Sciences, University of St. Andrews, North Haugh, St. Andrews, Fife, Scotland, UK.
      Journal
      IUBMB Life
      IUBMB life
      Wiley-Blackwell
      1521-6551
      1521-6543
      Jun 2010
      : 62
      : 6
      20503434 10.1002/iub.337

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