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      Hydrogels: from controlled release to pH-responsive drug delivery

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      Drug Discovery Today

      Elsevier BV

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          Abstract

          Hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Besides exhibiting swelling-controlled drug release, hydrogels also show stimuli-responsive changes in their structural network and hence, the drug release. Because of large variations in physiological pH at various body sites in normal as well as pathological conditions, pH-responsive polymeric networks have been extensively studied. This review highlights the use of hydrogels (a class of polymeric systems) in controlled drug delivery, and their application in stimuli-responsive, especially pH-responsive, drug release.

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          Author and article information

          Journal
          Drug Discovery Today
          Drug Discovery Today
          Elsevier BV
          13596446
          May 2002
          May 2002
          : 7
          : 10
          : 569-579
          Article
          10.1016/S1359-6446(02)02255-9
          12047857
          © 2002

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