One pot synthesis of higher order quasi-block copolymer libraries via sequential RAFT polymerization in an automated synthesizer

Abstract

The utility of automated high-throughput methods for the one pot synthesis of functional polymers of increased complexity is reported.

Recently developed sequential reversible addition–fragmentation chain transfer (RAFT) polymerization protocols allow the rapid, fully unattended preparation of quasi-block copolymer libraries that cover a wide range of copolymer compositions in an automated synthesizer. This contribution explores the scope and limitations of this sequential approach for the synthesis of higher order quasi-multiblock copolymers (including copolymer sequences of BAB, CBABC, ABC and ABCD). These syntheses illustrate the utility of this high-throughput approach for the one pot synthesis of functional polymers of increased complexity. Additionally, the use of this experimental technique for method development is highlighted.