Association of Selective Serotonin Reuptake Inhibitors With the Risk for Spontaneous Intracranial Hemorrhage

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Abstract

Selective serotonin reuptake inhibitors (SSRIs) may increase the risk for spontaneous intracranial hemorrhage (ICH), an effect that is in theory linked to the strength of inhibition of serotonin reuptake of an antidepressant. However, whether antidepressants that are strong inhibitors of serotonin reuptake actually increase the risk for ICH and the effect of concomitant use of antithrombotics are unknown.

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Journal

Title: JAMA Neurology

Abbreviated Title: JAMA Neurol

Publisher: American Medical Association (AMA)

ISSN (Print): 2168-6149

Publication date Created: February 01 2017

Publication date (Print): February 01 2017

Volume: 74

Issue: 2

Page: 173

Affiliations

[1 ]Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada2Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada3Department of Epidemiology and Biostatistics, McGill University, Montréal, Québec, Canada

[2 ]Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada

[3 ]Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada3Department of Epidemiology and Biostatistics, McGill University, Montréal, Québec, Canada

Article

DOI: 10.1001/jamaneurol.2016.4529

PubMed ID: 27918771

SO-VID: fd99b8a3-9980-466d-a99e-44282a3a4096

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