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      Catalytic Asymmetric Dearomatization Reactions

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      Angewandte Chemie International Edition

      Wiley-Blackwell

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          Asymmetric transition-metal-catalyzed allylic alkylations: applications in total synthesis.

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            Dearomatization Strategies in the Synthesis of Complex Natural Products

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              Collective synthesis of natural products by means of organocascade catalysis.

              Organic chemists are now able to synthesize small quantities of almost any known natural product, given sufficient time, resources and effort. However, translation of the academic successes in total synthesis to the large-scale construction of complex natural products and the development of large collections of biologically relevant molecules present significant challenges to synthetic chemists. Here we show that the application of two nature-inspired techniques, namely organocascade catalysis and collective natural product synthesis, can facilitate the preparation of useful quantities of a range of structurally diverse natural products from a common molecular scaffold. The power of this concept has been demonstrated through the expedient, asymmetric total syntheses of six well-known alkaloid natural products: strychnine, aspidospermidine, vincadifformine, akuammicine, kopsanone and kopsinine. ©2011 Macmillan Publishers Limited. All rights reserved
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                Author and article information

                Journal
                Angewandte Chemie International Edition
                Angew. Chem. Int. Ed.
                Wiley-Blackwell
                14337851
                December 14 2012
                December 14 2012
                : 51
                : 51
                : 12662-12686
                Article
                10.1002/anie.201204822
                © 2012
                Product

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