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      Cultured striatal neurons containing NADPH-diaphorase or acetylcholinesterase are selectively resistant to injury by NMDA receptor agonists

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      Brain Research
      Elsevier BV

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          Abstract

          Cultured striatal neurons containing either NADPH-diaphorase or acetylcholinesterase were more resistant to injury by N-methyl-D-aspartate (NMDA) or quinolinate, than the general striatal neuronal population, although this resistance was not absolute and could be overcome by intense toxic exposure. Neurons containing NADPH-diaphorase, but not neurons containing acetylcholinesterase, also exhibited heightened vulnerability to injury by kainate. Given recent evidence that diaphorase- and cholinesterase-containing striatal neurons are selectively spared in Huntington's disease, our results strengthen the possibility that NMDA receptor-mediated neurotoxicity may participate in the pathogenesis of that disease.

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          Author and article information

          Journal
          Brain Research
          Brain Research
          Elsevier BV
          00068993
          April 1988
          April 1988
          : 446
          : 2
          : 374-378
          Article
          10.1016/0006-8993(88)90897-9
          2836034
          fdeb3de3-6c25-47ca-a9f0-1efb6fffcbc0
          © 1988

          https://www.elsevier.com/tdm/userlicense/1.0/

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