Cd, Pb and Hg Biomonitoring in Fish of the Mediterranean Region and Risk Estimations on Fish Consumption

The history of aquatic environmental pollution goes back to the very beginning of the history of human civilization. However, aquatic pollution did not receive much attention until a threshold level was reached with adverse consequences on the ecosystems and organisms. Aquatic pollution has become a global concern, but even so, most developing nations are still producing huge pollution loads and the trends are expected to increase. Knowledge of the pollution sources and impacts on ecosystems is important not only for a better understanding on the ecosystem responses to pollutants but also to formulate prevention measures. Many of the sources of aquatic pollutions are generally well known and huge effort has been devoted to the issue. However, new concepts and ideas on environmental pollution are emerging (e.g., biological pollution) with a corresponding need for an update of the knowledge. The present paper attempts to provide an easy-to-follow depiction on the various forms of aquatic pollutions and their impacts on the ecosystem and organisms.

Cadmium (Cd) is a heavy metal that has received considerable concern environmentally and occupationally. Cd has a long biological half-life mainly due to its low rate of excretion from the body. Thus, prolonged exposure to Cd will cause toxic effect due to its accumulation over time in a variety of tissues, including kidneys, liver, central nervous system (CNS), and peripheral neuronal systems. Cd can be uptaken from the nasal mucosa or olfactory pathways into the peripheral and central neurons; for the latter, Cd can increase the blood brain barrier (BBB) permeability. However, mechanisms underlying Cd neurotoxicity remain not completely understood. Effect of Cd neurotransmitter, oxidative damage, interaction with other metals such as cobalt and zinc, estrogen-like, effect and epigenetic modification may all be the underlying mechanisms. Here, we review the in vitro and in vivo evidence of neurotoxic effects of Cd. The available finding indicates the neurotoxic effects of Cd that was associated with both biochemical changes of the cell and functional changes of central nervous system, suggesting that neurotoxic effects may play a role in the systemic toxic effects of the exposure to Cd, particularly the long-term exposure.

Metals are being utilized of ways in industries and agriculture; particularly heavy metals such as mercury, cadmium, lead and arsenic constitute a significant potential threat to human health because they are associated to many adverse effects on health. The consumption of fish is recommended because it is a good source of omega-3 fatty acids, which have been associated with health benefits due to its cardio-protective effects. However, the content of heavy metals discovered in some fish makes it difficult to establish clearly the role of fish consumption on a healthy diet. Therefore the present mini-review accounts for the recent evidence of the effect of these toxic metals on the human health and their possible implications in fish consumption. Copyright © 2008 Elsevier B.V. All rights reserved.