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      The microscopic and ultramicroscopic changes in the skeletal muscles, caused by heavy metal salts

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          Abstract

          Purpose

          The article is devoted to study the structural changes in the skeletal muscles caused by heavy metal salts.

          Materials and methods

          The study was conducted on 72 mature male rats. The experimental groups were given to drink water with combinations of heavy metal salts for one, two and three months. This type of water is typical for the water basins in the northern districts of the Sumy region. The study of morphological changes in the striated muscles was concluded using light and scanning electron microscopy.

          Results

          The data analysis revealed that a prolonged duration of negative factor could intensify sclerotic and edematous processes. The structure of muscle fibers was destroyed, nuclei were deformed and placed irregularly, and many petechial hemorrhages occurred. Besides, cross-striation was irregular, I and A bands were deformed and destroyed, H band was hardly visualized. The inner mitochondrial membrane and cristae become deformed. The symplastic nuclei were placed irregularly within sarcoplasm. Besides, they were swollen. Against swollen and enlarged symplastic nuclei, pyknotic nuclei were also found. The structures of sarcoplasmic reticulum were mainly dilated with deformed and ruptured areas.

          Conclusion

          Our study approves that high concentrations of heavy metal salts have a destructive influence on the skeletal striated muscles.

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          Author and article information

          Journal
          imas
          1646
          Interventional Medicine and Applied Science
          Interventional Medicine and Applied Science
          Akadémiai Kiadó (Budapest )
          2061-1617
          2061-5094
          30 June 2016
          : 8
          : 2
          : 82-88
          Affiliations
          [1 ]Department of Normal Anatomy with a Topographical Anatomy and Operational Surgery Course, Sumy State University , Sumy, Ukraine
          [2 ]Department of Applied Physics, Sumy State University , Sumy, Ukraine
          [3 ]Department of Pathology, Sumy State University , Sumy, Ukraine
          [4 ] Sumy State University , Sumy, Ukraine
          Author notes
          [* ]Corresponding author: Mykola Lyndin, MD, PhD; Rymskogo-Korsakova St., 2, 40007 Sumy, Ukraine; Phone: +380 977 155524; E-mail: lyndin_nikolay@ 123456ukr.net
          Article
          10.1556/1646.8.2016.2.7
          5370355
          28386464
          fe05b091-2a43-4f8e-804a-9e9364ece714
          © 2016 The Author(s)

          This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited.

          2061-1617

          Page count
          Figures: 5, Tables: 1, Equations: 0, References: 26, Pages: xx
          Funding
          Funding sources: No financial support was received for this study.
          Categories
          Original Paper

          Medicine,Immunology,Health & Social care,Microbiology & Virology,Infectious disease & Microbiology
          ultrastructure,striated muscle,rats,heavy metal salts,electron microscope

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