20
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Macrophage recruitment in obese adipose tissue.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Obesity is characterized as a chronic state of low-grade inflammation with progressive immune cell infiltration into adipose tissues. Adipose tissue macrophages play critical roles in the establishment of the chronic inflammatory state and metabolic dysfunctions. The novel discovery that pro-inflammatory macrophages are recruited to obese adipose tissue prompted an increased interest in the interplay between immune cells and metabolism. Since this discovery, many works have been published investigating the factors that lead to macrophage recruitment, the phenotypic change of adipose tissue macrophages, and metabolic dysfunctions. Adipokines and chemokines are key mediators that play crucial roles in crosstalk between adipocytes and macrophages and in regulating the adipose tissue inflammation. In the present review, we discuss the obesity-mediated adipose tissue remodelling, and particularly, the role of adipokines/chemokines in macrophage recruitment to obese adipose tissue. This review provides new insights into the physiological role of these factors and identifies a potential therapeutic target for obesity and associated disorders.

          Related collections

          Author and article information

          Journal
          Obes Rev
          Obesity reviews : an official journal of the International Association for the Study of Obesity
          1467-789X
          1467-7881
          Feb 2015
          : 16
          : 2
          Affiliations
          [1 ] Division of Environmental Health Sciences, College of Public Health, Ohio State University, Columbus, Ohio, USA; Molecular, Cellular, and Developmental Biology Program, College of Medicine, Ohio State University, Columbus, Ohio, USA.
          Article
          NIHMS644514
          10.1111/obr.12242
          25586506
          fe0d045f-52ab-4e24-bf06-b751d91f36ed
          © 2015 International Association for the Study of Obesity (IASO).
          History

          Adipokine,chemokine,macrophage,obesity
          Adipokine, chemokine, macrophage, obesity

          Comments

          Comment on this article