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      Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond.

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          Abstract

          The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has been implicated in disorders such as cancer and inflammatory diseases. This Review discusses the ways in which S1P might be therapeutically targeted - for example, via the development of chemical inhibitors that target the generation, transport and degradation of S1P and via the development of specific S1P receptor agonists. We also highlight recent conflicting results observed in preclinical studies targeting S1P and discuss ongoing clinical trials in this field.

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          Author and article information

          Journal
          Nat Rev Drug Discov
          Nature reviews. Drug discovery
          Springer Science and Business Media LLC
          1474-1784
          1474-1776
          Sep 2013
          : 12
          : 9
          Affiliations
          [1 ] 1] Department of Biochemistry and Molecular Biology, Massey Cancer Center, Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, 2-017 Sanger Hall, Richmond, Virginia 23298, USA. [2].
          Article
          nrd4099 NIHMS548083
          10.1038/nrd4099
          3908769
          23954895
          fe14414a-e99b-4209-b2ff-425afb3fcf5f
          History

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