<div class="section">
<a class="named-anchor" id="d9796061e144">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d9796061e145">Background</h5>
<p id="d9796061e147">Aqueous shunts are employed to control intraocular pressure (IOP)
for people with
primary or secondary glaucomas who fail or are not candidates for standard surgery.
</p>
</div><div class="section">
<a class="named-anchor" id="d9796061e149">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d9796061e150">Objectives</h5>
<p id="d9796061e152">To assess the effectiveness and safety of aqueous shunts for
reducing IOP in glaucoma
compared with standard surgery, another type of aqueous shunt, or modification to
the aqueous shunt procedure.
</p>
</div><div class="section">
<a class="named-anchor" id="d9796061e154">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d9796061e155">Search methods</h5>
<p id="d9796061e157">We searched CENTRAL (which contains the Cochrane Eyes and Vision
Trials Register)
(2016, Issue 8), MEDLINE Ovid (1946 to August 2016), Embase.com (1947 to August 2016),
PubMed (1948 to August 2016), LILACS (Latin American and Caribbean Health Sciences
Literature Database) (1982 to August 2016), ClinicalTrials.gov (www.clinicaltrials.gov);
searched 15 August 2016, and the World Health Organization (WHO) International
Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en); searched
15 August 2016. We did not use any date or language restrictions in the
electronic search for trials. We last searched the electronic databases on 15 August
2016. We also searched the reference lists of identified trial reports and the Science
Citation Index to find additional trials.
</p>
</div><div class="section">
<a class="named-anchor" id="d9796061e165">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d9796061e166">Selection criteria</h5>
<p id="d9796061e168">We included randomized controlled trials that compared various
types of aqueous shunts
with standard surgery or to each other in eyes with glaucoma.
</p>
</div><div class="section">
<a class="named-anchor" id="d9796061e170">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d9796061e171">Data collection and analysis</h5>
<p id="d9796061e173">Two review authors independently screened search results for
eligibility, assessed
the risk of bias, and extracted data from included trials. We contacted trial investigators
when data were unclear or not reported. We graded the certainty of the evidence using
the GRADE approach. We followed standard methods as recommended by Cochrane.
</p>
</div><div class="section">
<a class="named-anchor" id="d9796061e175">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d9796061e176">Main results</h5>
<p id="d9796061e178">We included 27 trials with a total of 2099 participants with
mixed diagnoses and comparisons
of interventions. Seventeen studies reported adequate methods of randomization, and
seven reported adequate allocation concealment. Data collection and follow‐up times
varied.
</p>
<p id="d9796061e180">Four trials compared an aqueous shunt (Ahmed or Baerveldt) with
trabeculectomy, of
which three reported one‐year outcomes. At one‐year, the difference in IOP between
aqueous shunt groups and trabeculectomy groups was uncertain (mean difference (MD)
2.55 mmHg, 95% confidence interval (CI) ‐0.78 to 5.87; 380 participants; very low‐certainty
evidence). The difference in logMAR visual acuity was also uncertain (MD 0.12 units,
95% CI ‐0.07 to 0.31; 380 participants; very low‐certainty evidence). In two trials,
the difference in visual field score was uncertain (MD ‐0.25, 95% CI ‐1.91 to 1.40;
196 participants; very low‐certainty evidence). The mean number of antiglaucoma medications
was higher in the aqueous shunt group than the trabeculectomy group in one trial (MD
0.80, 95% CI 0.48 to 1.12; 184 participants; low‐certainty evidence). The effect on
needing additional glaucoma surgery was uncertain between groups in two trials (risk
ratio (RR) 0.24, 95% CI 0.04 to 1.36; 329 participants; very low‐certainty evidence).
In one trial, fewer total adverse events were reported in the aqueous shunt group
than the trabeculectomy group (RR 0.59, 95% CI 0.43 to 0.81; 212 participants; very
low‐certainty evidence). No trial reported quality‐of‐life outcomes at one‐year follow‐up.
</p>
<p id="d9796061e182">Two trials that compared the Ahmed implant with the Baerveldt
implant for glaucoma
found higher mean IOP in the Ahmed group at one‐year follow‐up (MD 2.60 mmHg, 95%
CI 1.58 to 3.62; 464 participants; moderate‐certainty evidence). The difference in
logMAR visual acuity was uncertain between groups (MD ‐0.07 units, 95% CI ‐0.27 to
0.13; 501 participants; low‐certainty evidence). The MD in number of antiglaucoma
medications was within one between groups (MD 0.35, 95% CI 0.11 to 0.59; 464 participants;
moderate‐certainty evidence). More participants in the Ahmed group required additional
glaucoma surgery than the Baerveldt group (RR 2.77, 95% CI 1.02 to 7.54; 514 participants;
moderate‐certainty evidence). The two trials reported specific adverse events but
not overall number of adverse events. Neither trial reported visual field or quality‐of‐life
outcomes at one‐year follow‐up.
</p>
<p id="d9796061e184">One trial compared the Ahmed implant with the Molteno implant
for glaucoma over two‐year
follow‐up. Mean IOP was higher in the Ahmed group than the Molteno group (MD 1.64
mmHg, 95% CI 0.85 to 2.43; 57 participants; low‐certainty evidence). The differences
in logMAR visual acuity (MD 0.08 units, 95% CI ‐0.24 to 0.40; 57 participants; very
low‐certainty evidence) and mean deviation in visual field (MD ‐0.18 dB, 95% CI ‐3.13
to 2.77; 57 participants; very low‐certainty evidence) were uncertain between groups.
The mean number of antiglaucoma medications was also uncertain between groups (MD
‐0.38, 95% CI ‐1.03 to 0.27; 57 participants; low‐certainty evidence). The trial did
not report the proportion needing additional glaucoma surgery, total adverse events,
or quality‐of‐life outcomes.
</p>
<p id="d9796061e186">Two trials compared the double‐plate Molteno implant with the
Schocket shunt for glaucoma;
one trial reported outcomes only at six‐month follow‐up, and the other did not specify
the follow‐up time. At six‐months, mean IOP was lower in the Molteno group than the
Schocket group (MD ‐2.50 mmHg, 95% CI ‐4.60 to ‐0.40; 115 participants; low‐certainty
evidence). Neither trial reported the proportion needing additional glaucoma surgery,
total adverse events, or visual acuity, visual field, or quality‐of‐life outcomes.
</p>
<p id="d9796061e188">The remaining 18 trials evaluated modifications to aqueous shunts,
including 14 trials
of Ahmed implants (early aqueous suppression versus standard medication regimen, 2
trials; anti‐vascular endothelial growth factor agent versus none, 4 trials; corticosteroids
versus none, 2 trials; shunt augmentation versus none, 3 trials; partial tube ligation
versus none, 1 trial; pars plana implantation versus conventional implantation, 1
trial; and model M4 versus model S2,1 trial); 1 trial of 500 mm
<sup>2</sup> Baerveldt versus 350 mm
<sup>2</sup> Baerveldt; and 3 trials of Molteno implants (single‐plate with oral corticosteroids
versus single‐plate without oral corticosteroids, 1 trial; double‐plate versus single‐plate,
1 trial; and pressure‐ridge versus double‐plate with tube ligation, 1 trial).
</p>
</div><div class="section">
<a class="named-anchor" id="d9796061e196">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d9796061e197">Authors' conclusions</h5>
<p id="d9796061e199">Information was insufficient to conclude whether there are differences
between aqueous
shunts and trabeculectomy for glaucoma treatment. While the Baerveldt implant may
lower IOP more than the Ahmed implant, the evidence was of moderate‐certainty and
it is unclear whether the difference in IOP reduction is clinically significant. Overall,
methodology and data quality among existing randomized controlled trials of aqueous
shunts was heterogeneous across studies, and there are no well‐justified or widely
accepted generalizations about the superiority of one surgical procedure or device
over another.
</p>
</div><p id="d9796061e205">
<b>What was the aim of this review?</b> We aimed to learn: 1. how successful and safe
aqueous shunts are for lowering eye
pressure when compared with standard surgery (trabeculectomy); 2. how successful and
safe various types of aqueous shunts are when compared with each other; and 3. how
successful and safe aqueous shunts are when the procedure is modified.
</p><p id="d9796061e210">Our search for relevant studies identified 27 trials.</p><p
id="d9796061e212">
<b>Key messages</b> It is uncertain if aqueous shunts are more effective or are safer
than standard surgery
(trabeculectomy) for glaucoma (very low‐certainty evidence). The Baerveldt and Molteno
aqueous shunts may reduce eye pressure more than the Ahmed shunt (moderate‐ and low‐certainty
evidence).
</p><p id="d9796061e217">
<b>What did we study in this review?</b> Glaucoma is a condition caused by the build‐up
of fluid in the front part of the
eye. This build‐up of fluid raises the eye pressure, which can lead to damage of the
optic nerve and vision loss. Some people with glaucoma need surgery to reduce eye
pressure. Standard surgery is called trabeculectomy. In trabeculectomy, a small hole
is made to the tissue in the front of the eye to create a drain for the fluid. Alternatively,
a small implant called an aqueous shunt can be inserted into the eye to create a pathway
for fluid to drain.
</p><p id="d9796061e222">
<b>What were the main results of this review?</b> We found 27 studies. Four studies
compared an aqueous shunt (either Ahmed or Baerveldt)
with standard surgery (trabeculectomy). Five trials compared two different types of
shunt (Ahmed versus Baerveldt, Ahmed versus Molteno, Molteno versus Schocket). Eighteen
studies compared modifications to aqueous shunts.
</p><p id="d9796061e227">The results of the review were as follows. 1. The evidence
comparing aqueous shunts
with trabeculectomy was of very low‐certainty. 2. There were some differences between
different implants: the Baerveldt and Molteno implants may work better than the Ahmed
implant; eye pressure was reduced more and fewer antiglaucoma medications were needed
(moderate‐ and low‐certainty evidence). The Molteno implant may work better than the
Schocket implant (low‐certainty evidence on eye pressure only). 3. Although 18 trials
looked at modifications to aqueous shunts, many different modifications were studied,
and the evidence was inconclusive.
</p><p id="d9796061e229">
<b>How up‐to‐date is this review?</b> We searched for studies that had been published
up to 15 August 2016.
</p>