Autotaxin interacts with lipoprotein(a) and oxidized phospholipids in predicting the risk of calcific aortic valve stenosis in patients with coronary artery disease.

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Abstract

Studies have shown that lipoprotein(a) [Lp(a)], an important carrier of oxidized phospholipids, is causally related to calcific aortic valve stenosis (CAVS). Recently, we found that Lp(a) mediates the development of CAVS through autotaxin (ATX).

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Journal

Journal ID (iso-abbrev): J. Intern. Med.

Title: Journal of internal medicine

Publisher: Wiley

ISSN (Electronic): 1365-2796

ISSN (Print): 0954-6820

Publication date (Electronic): Nov 2016

Volume: 280

Issue: 5

Affiliations

[1 ] Laboratory of Cardiovascular Pathobiology Quebec Heart and Lung Institute/Research Center, Department of Surgery, Quebec, Canada.

[2 ] Department of Medicine, Laval University, Quebec, Canada.

[3 ] Statistical Consulting Service Unit at the Quebec Heart and Lung Institute/Research Center, Laval University, Quebec, Canada.

[4 ] University of California San Diego, La Jolla, CA, USA.

[5 ] Department of Molecular Medicine, Laval University, Quebec, Canada.

[6 ] Laboratory of Cardiovascular Pathobiology Quebec Heart and Lung Institute/Research Center, Department of Surgery, Quebec, Canada. patrick.mathieu@chg.ulaval.ca.

Article

DOI: 10.1111/joim.12519

PubMed ID: 27237700

SO-VID: fe3785ec-3d8c-4abd-b224-720e21473ad0

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Keywords: oxidized phospholipids,lipoprotein(a),calcific aortic valve stenosis,calcific aortic valve disease,autotaxin

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Keywords: oxidized phospholipids, lipoprotein(a), calcific aortic valve stenosis, calcific aortic valve disease, autotaxin

Autotaxin interacts with lipoprotein(a) and oxidized phospholipids in predicting the risk of calcific aortic valve stenosis in patients with coronary artery disease.

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