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      Identification of irisin as a therapeutic agent that inhibits oxidative stress and fibrosis in a murine model of chronic pancreatitis.

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          Abstract

          Abnormal activation of pancreatic stellate cells (PSCs) plays a crucial role in the pathogenesis of chronic pancreatitis (CP). Irisin, an exercise-induced hormone, has been shown to mitigate liver fibrosis by inhibiting the activation of hepatic stellate cells. However, the effect of irisin in CP has not been evaluated.

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          Author and article information

          Journal
          Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
          Elsevier BV
          1950-6007
          0753-3322
          Jun 2020
          : 126
          Affiliations
          [1 ] National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China; Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
          [2 ] Department of Orthopedic, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
          [3 ] Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China. Electronic address: woozheng@mail.xjtu.edu.cn.
          [4 ] National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China. Electronic address: rwu001@mail.xjtu.edu.cn.
          Article
          S0753-3322(20)30293-6
          10.1016/j.biopha.2020.110101
          32199226
          fe586662-953c-43a7-bc53-fbde410ee849
          History

          Fibrosis,Stellate cell,Oxidative stress,Irisin,ER stress,Chronic pancreatitis

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