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Abstract
<p class="first" id="d5940839e61">G-quadruplex (G4) structures are of general importance
in chemistry and biology, such
as in biosensing, gene regulation, and cancers. Although a large repertoire of G4-binding
tools has been developed, no aptamer has been developed to interact with G4. Moreover,
the G4 selectivity of current toolkits is very limited. Herein, we report the first
l-RNA aptamer that targets a d-RNA G-quadruplex (rG4). Using TERRA rG4 as an example,
our results reveal that this l-RNA aptamer, Ap3-7, folds into a unique secondary structure,
exhibits high G4 selectivity and effectively interferes with TERRA-rG4-RHAU53 binding.
Our approach and findings open a new door in further developing G4-specific tools
for diverse applications.
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