0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Blood-Spotted Filter Paper Measurements of Thyroxine and Thyroid-Stimulating Hormone in the Follow-Up of Children with Congenital Hypothyroidism

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Neonatal screening for congenital hypothyroidism using T<sub>4</sub> and TSH measurements from blood-spotted filter paper is a well-established method. However, it has not been used to monitor T<sub>4</sub> and TSH concentrations in the follow-up of these children. In 22 treated children with congenital hypothyroidism whom we follow up in our Clinic, T<sub>4</sub> and TSH concentrations were concomitantly measured from venous blood and blood-spotted filter paper. There was a significant positive correlation between both T<sub>4</sub> and TSH measurements from venous blood versus blood-spotted filter paper (r = 0.7, p = 0.001; r = 0.78, p < 0.05). Filter paper T<sub>4</sub> values above 7 µg/dl could exclude hypothyroxinemia in 98% of the specimens. When TSH values were above 10 µU/ml, it was confirmed in 94% of the specimens, and when they were above 20 µU/ml, it was confirmed in 97% of the specimens. Measurements of both filter paper T<sub>4</sub> and filter paper TSH did not increase the reliability of the results obtained by examining the two hormones separately. We therefore suggest that filter paper T<sub>4</sub> and/or TSH measurements have distinct advantages in monitoring the treatment of children with congenital hypothyroidism. It can be performed in the community, enabling assistance in the follow-up of children in remote areas who are unable to show up for serum tests. The results are obtained quickly and allow improved follow-up by providing useful information such as excluding hypothyroxenemia or suggesting the possibility of noncompliance, and by a psychological effect on parents. However, they cannot replace serum T<sub>4</sub> and TSH measurements altogether.

          Related collections

          Author and article information

          Journal
          HRE
          10.1159/issn.0018-5051
          Hormone Research in Paediatrics
          S. Karger AG
          0018-5051
          2571-6603
          1990
          1990
          02 December 2008
          : 34
          : 5-6
          : 219-223
          Affiliations
          aPediatric Endocrinology Unit, Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer; bDepartment of Statistics, University of Tel-Aviv, Israel
          Article
          181829 Horm Res 1990;34:219–223
          10.1159/000181829
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

          Comments

          Comment on this article