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      Homozygous ALDH2*2 Is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men.

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          Abstract

          The *2 allele of the aldehyde dehydrogenase 2 gene (ALDH2) is the most common variant in Asian populations. The variant resulting in enzyme dysfunction was highly related to coronary artery disease. Recently, genome-wide association studies also discovered that the 12q24 locus near ALDH2 gene was associated with hypertension and ischemic stroke. This study intended to further investigate whether the above variant of ALDH2 increases the risk for ischemic stroke in Taiwanese.

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          Author and article information

          Journal
          Stroke
          Stroke
          Ovid Technologies (Wolters Kluwer Health)
          1524-4628
          0039-2499
          Sep 2016
          : 47
          : 9
          Affiliations
          [1 ] From the Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan (Y.-F.S., C.-C.L., G.-S.P.); Department of Neurology (Y.-F.S., J.-T.L., G.-S.P.) and Division of Endocrinology and Metabolism, Department of Internal Medicine (Y.-J.H.), Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Department of Neurology, College of Medicine, Taipei Medical University and Shuang Ho Hospital, Taiwan (C.-J.H.); Stroke Center and Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan (J.-S.J.); School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taiwan (H.-Y.C.); and Division of Neurology, Department of Internal Medicine, Taipei Veterans General Hospital, Hsinchu Branch, Hsinchu County, Taiwan (G.-S.P.).
          [2 ] From the Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan (Y.-F.S., C.-C.L., G.-S.P.); Department of Neurology (Y.-F.S., J.-T.L., G.-S.P.) and Division of Endocrinology and Metabolism, Department of Internal Medicine (Y.-J.H.), Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Department of Neurology, College of Medicine, Taipei Medical University and Shuang Ho Hospital, Taiwan (C.-J.H.); Stroke Center and Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan (J.-S.J.); School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taiwan (H.-Y.C.); and Division of Neurology, Department of Internal Medicine, Taipei Veterans General Hospital, Hsinchu Branch, Hsinchu County, Taiwan (G.-S.P.). tsghpeng@gmail.com hychiou@tmu.edu.tw.
          Article
          STROKEAHA.116.013204
          10.1161/STROKEAHA.116.013204
          27486170
          fe6ba63c-5481-4bd3-9e6c-56a86a064125
          History

          Taiwan,aldehyde dehydrogenase,genetic association studies,men,risk factors

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