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      Antimicrobial Treatment of Polymeric Medical Devices by Silver Nanomaterials and Related Technology

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          Abstract

          Antimicrobial biocompatible polymers form a group of highly desirable materials in medicinal technology that exhibit interesting thermal and mechanical properties, and high chemical resistance. There are numerous types of polymers with antimicrobial activity or antimicrobial properties conferred through their proper modification. In this review, we focus on the second type of polymers, especially those whose antimicrobial activity is conferred by nanotechnology. Nanotechnology processing is a developing area that exploits the antibacterial effects of broad-scale compounds, both organic and inorganic, to form value-added medical devices. This work gives an overview of nanostructured antimicrobial agents, especially silver ones, used together with biocompatible polymers as effective antimicrobial composites in healthcare. The bactericidal properties of non-conventional antimicrobial agents are compared with those of conventional ones and the advantages and disadvantages are discussed.

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          Most cited references108

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          One-Dimensional Nanostructures: Synthesis, Characterization, and Applications

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            Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.

            In this work we investigated the antibacterial properties of differently shaped silver nanoparticles against the gram-negative bacterium Escherichia coli, both in liquid systems and on agar plates. Energy-filtering transmission electron microscopy images revealed considerable changes in the cell membranes upon treatment, resulting in cell death. Truncated triangular silver nanoplates with a {111} lattice plane as the basal plane displayed the strongest biocidal action, compared with spherical and rod-shaped nanoparticles and with Ag(+) (in the form of AgNO(3)). It is proposed that nanoscale size and the presence of a {111} plane combine to promote this biocidal property. To our knowledge, this is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and our results demonstrate that silver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
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              Silver as antibacterial agent: ion, nanoparticle, and metal.

              The antibacterial action of silver is utilized in numerous consumer products and medical devices. Metallic silver, silver salts, and also silver nanoparticles are used for this purpose. The state of research on the effect of silver on bacteria, cells, and higher organisms is summarized. It can be concluded that the therapeutic window for silver is narrower than often assumed. However, the risks for humans and the environment are probably limited. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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                Author and article information

                Contributors
                Role: Academic Editor
                Role: Academic Editor
                Journal
                Int J Mol Sci
                Int J Mol Sci
                ijms
                International Journal of Molecular Sciences
                MDPI
                1422-0067
                15 February 2017
                February 2017
                : 18
                : 2
                : 419
                Affiliations
                [1 ]Department of Solid State Engineering, University of Chemistry and Technology Prague, Prague 166 28, Czech Republic; polivkoa@ 123456vscht.cz (M.P.); marek.staszek@ 123456vscht.cz (M.S.); vaclav.svorcik@ 123456vscht.cz (V.Š.)
                [2 ]Institute of Hydrobiology, Biology Centre of the AS CR, Ceske Budejovice 370 05, Czech Republic; hubacektom@ 123456gmail.com
                Author notes
                [* ]Correspondence: Jakub.Siegel@ 123456vscht.cz ; Tel.: +42-0220-445-149
                Article
                ijms-18-00419
                10.3390/ijms18020419
                5343953
                28212308
                fe6f7ab3-051a-4a70-995c-4bf04f607275
                © 2017 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 08 December 2016
                : 09 February 2017
                Categories
                Review

                Molecular biology
                antimicrobials,medical devices,nanostructures,polymers,modification,biocompatibility
                Molecular biology
                antimicrobials, medical devices, nanostructures, polymers, modification, biocompatibility

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