AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma.

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Abstract

Head and neck squamous cell carcinoma (HNSCC) represents the eighth most common malignancy worldwide. Standard-of-care treatments for patients with HNSCC include surgery, radiation, and chemotherapy. In addition, the anti-EGFR monoclonal antibody cetuximab is often used in combination with these treatment modalities. Despite clinical success with these therapeutics, HNSCC remains a difficult malignancy to treat. Thus, identification of new molecular targets is critical.

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Journal

Journal ID (iso-abbrev): Clin. Cancer Res.

Title: Clinical cancer research : an official journal of the American Association for Cancer Research

ISSN: 1078-0432

ISSN (Print): 1078-0432

Publication date (Electronic): Jun 1 2015

Volume: 21

Issue: 11

Affiliations

[1 ] Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

[2 ] Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Department of Medical Physics, University of Wisconsin, Madison, Wisconsin.

[3 ] Department of Medical Physics, University of Wisconsin, Madison, Wisconsin.

[4 ] Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin.

[5 ] Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin.

[6 ] Departments of Medicine and Pathology, University of Southern California, Los Angeles, California.

[7 ] Department of Pathology, University of Chicago Medical Center, Chicago, Illinois.

[8 ] Division of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, Illinois.

[9 ] Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. dlwheeler@wisc.edu.

Article

Publisher Item ID: 1078-0432.CCR-14-2648 Mid ID: NIHMS809134

DOI: 10.1158/1078-0432.CCR-14-2648

PMC ID: 5032632

PubMed ID: 25767293

SO-VID: fe73766f-57ad-4e95-94be-30385a24804b

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