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      Effect of Starvation and Subsequent Refeeding on Thyroid Function and Release of Hypothalamic Thyrotropin-Releasing Hormone

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          Abstract

          Effects of starvation on thyroid function were studied in 5- to 6-week-old (R× U) F<sub>1</sub> rats. Starvation lowered plasma TSH in female, but not in male rats. Plasma T<sub>4</sub> and T<sub>3</sub> levels decreased, whereas the dialysable T<sub>4</sub> fraction increased during starvation. Free T<sub>4</sub> (FT<sub>4</sub>) levels decreased rapidly in females, but only after prolonged fasting in male rats. Glucose decreased, and free fatty acid levels increased during starvation. Peripheral TRH levels did not change during food deprivation. Since effects of starvation were most apparent in young female rats, such rats were used to study hypothalamic TRH release during starvation and subsequent refeeding. Basal in vitro hypothalamic TRH secretion was less in starved rats than in control or refed animals. In vitro hypothalamic TRH release in medium with 56 ml KC1 increased 3-fold compared to basal release, and in these depolarization conditions TRH release was similar between hypothalami from control, starved and refed rats. In rats starved for 2 days, TRH level in hypophysial portal blood was lower than that of controls. Thus, diminished thyroid function during starvation may at least in part be caused by a reduced hypothalamic TRH release.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1992
          1992
          07 April 2008
          : 56
          : 3
          : 348-353
          Affiliations
          Department of Internal Medicine and Clinical Endocrinology, and Department of Endocrinology and Reproduction, Erasmus University, Rotterdam, The Netherlands
          Article
          126248 Neuroendocrinology 1992;56:348–353
          10.1159/000126248
          1436373
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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