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      Aldosterone Overproduction and CYP11B2 mRNA Overexpression in Vessels of Spontaneously Hypertensive Rats

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          Aldosterone is synthesized in extra-adrenal tissues such as blood vessels and brain. Damage to blood vessels could play a crucial role in perpetuating hypertension. In this study, we determined both aldosterone production and aldosterone synthase gene-CYP11B2 mRNA expression in vessels of spontaneously hypertensive rats (SHR). The results showed that aldosterone was overproduced in the vasculature of SHR, by means of ex vivo mesenteric artery perfusion, HPLC, and RIA, and that CYP11B2 mRNA expression was upregulated in aortas of SHR, confirmed by RT-PCR and Southern blot.

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          Mineralocorticoids, salt and high blood pressure

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            Catecholamine-mediated constrictor effects of aldosterone on vascular smooth muscle


              Author and article information

              Horm Res Paediatr
              Hormone Research in Paediatrics
              S. Karger AG
              July 1998
              09 July 1998
              : 50
              : 1
              : 28-31
              a Department of Cardiology, Nanfang Hospital, The First Military Medical University, Guangzhou, People’s Republic of China; b Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan
              23197 Horm Res 1998;50:28–31
              © 1998 S. Karger AG, Basel

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              Pages: 4
              Original Paper


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