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      The effect of antimicrobial additives on the properties of dental glass-ionomer cements: a review

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          Abstract

          Aim: The aim of this article is to review the literature on the use of antimicrobial additives in glass-ionomer dental cements.

          Method: An electronic search between 1987 and the end of 2017 was performed using PubMed, Web of Science and Google search engines with the terms glass-ionomer, glass polyalkenoate, antibacterial and antimicrobial as the key words. The search was refined by excluding the majority of references concerned with cement antimicrobial properties only. Extra papers already known to the authors were added to those considered.

          Results: A total of 92 relevant articles have been cited in the review of which 55 are specifically concerned with the enhancement of antibacterial properties of glass-ionomers, both conventional and resin-modified, with additives. In addition, information is included on the uses of glass-ionomers and the biological properties of the antibacterial additives employed. There are several reports that show that additives are typically released by diffusion, and that a high proportion is usually left behind, trapped in the cement. Additives generally increase setting times of cements, and reduce mechanical properties. However, smaller amounts of additive have only slight effects and the longer-term durability of cements appears unaffected.

          Conclusion: Modified glass-ionomer cements seem to be acceptable for clinical use, especially in the Atraumatic Restorative Treatment (ART) technique.

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          Most cited references85

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          Dental caries: a dynamic disease process.

          Abstract Dental caries is a transmissible bacterial disease process caused by acids from bacterial metabolism diffusing into enamel and dentine and dissolving the mineral. The bacteria responsible produce organic acids as a by-product of their metabolism of fermentable carbohydrates. The caries process is a continuum resulting from many cycles of demineralization and remineralization. Demineralization begins at the atomic level at the crystal surface inside the enamel or dentine and can continue unless halted with the end-point being cavitation. There are many possibilities to intervene in this continuing process to arrest or reverse the progress of the lesion. Remineralization is the natural repair process for non-cavitated lesions, and relies on calcium and phosphate ions assisted by fluoride to rebuild a new surface on existing crystal remnants in subsurface lesions remaining after demineralization. These remineralized crystals are acid resistant, being much less soluble than the original mineral.
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            Biocompatibility of Advanced Manufactured Titanium Implants—A Review

            Titanium (Ti) and its alloys may be processed via advanced powder manufacturing routes such as additive layer manufacturing (or 3D printing) or metal injection moulding. This field is receiving increased attention from various manufacturing sectors including the medical devices sector. It is possible that advanced manufacturing techniques could replace the machining or casting of metal alloys in the manufacture of devices because of associated advantages that include design flexibility, reduced processing costs, reduced waste, and the opportunity to more easily manufacture complex or custom-shaped implants. The emerging advanced manufacturing approaches of metal injection moulding and additive layer manufacturing are receiving particular attention from the implant fabrication industry because they could overcome some of the difficulties associated with traditional implant fabrication techniques such as titanium casting. Using advanced manufacturing, it is also possible to produce more complex porous structures with improved mechanical performance, potentially matching the modulus of elasticity of local bone. While the economic and engineering potential of advanced manufacturing for the manufacture of musculo-skeletal implants is therefore clear, the impact on the biocompatibility of the materials has been less investigated. In this review, the capabilities of advanced powder manufacturing routes in producing components that are suitable for biomedical implant applications are assessed with emphasis placed on surface finishes and porous structures. Given that biocompatibility and host bone response are critical determinants of clinical performance, published studies of in vitro and in vivo research have been considered carefully. The review concludes with a future outlook on advanced Ti production for biomedical implants using powder metallurgy.
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              Quaternary Ammonium Compounds: An Antimicrobial Mainstay and Platform for Innovation to Address Bacterial Resistance.

              Quaternary ammonium compounds (QACs) have represented one of the most visible and effective classes of disinfectants for nearly a century. With simple preparation, wide structural variety, and versatile incorporation into consumer products, there have been manifold developments and applications of these structures. Generally operating via disruption of one of the most fundamental structures in bacteria-the cell membrane-leading to cell lysis and bacterial death, the QACs were once thought to be impervious to resistance. Developments over the past decades, however, have shown this to be far from the truth. It is now known that a large family of bacterial genes (generally termed qac genes) encode efflux pumps capable of expelling many QAC structures from bacterial cells, leading to a decrease in susceptibility to QACs; methods of regulation of qac transcription are also understood. Importantly, qac genes can be horizontally transferred via plasmids to other bacteria and are often transmitted alongside other antibiotic-resistant genes; this dual threat represents a significant danger to human health. In this review, both QAC development and QAC resistance are documented, and possible strategies for addressing and overcoming QAC-resistant bacteria are discussed.
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                Author and article information

                Journal
                Acta Biomater Odontol Scand
                Acta Biomater Odontol Scand
                IABO
                iabo20
                Acta Biomaterialia Odontologica Scandinavica
                Taylor & Francis
                2333-7931
                2019
                10 January 2019
                : 5
                : 1
                : 9-21
                Affiliations
                [a ]Department of Paediatric Dentistry, Faculty of Dentistry, Karadeniz Technical University , Trabzon, Turkey;
                [b ]Department of Paediatric and Preventive Dentistry, Faculty of Dental Medicine, St Cyril and St Methodius University , Skopje, Macedonia;
                [c ]Bluefield Centre for Biomaterials , London, United Kingdom;
                [d ]Dental Physical Sciences, Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London , London, United Kingdom
                Author notes
                CONTACT John W. Nicholson john.nicholson@ 123456bluefieldcentre.co.uk Bluefield Centre for Biomaterials , London, EC1N 8JY, United Kingdom; Dental Physical Sciences, Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, Mile End Road, London, E1 4NS, United Kingdom.
                Article
                1539623
                10.1080/23337931.2018.1539623
                6327935
                30652117
                fea516c8-4e6c-4933-8b44-91c3a605029b
                © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 09 July 2018
                : 10 October 2018
                Page count
                Figures: 5, Tables: 5, Pages: 20, Words: 9455
                Categories
                Review Article

                glass-ionomer,antimicrobial,mechanical properties
                glass-ionomer, antimicrobial, mechanical properties

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