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      Myogenic satellite cells: physiology to molecular biology.

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          Abstract

          Adult skeletal muscle has a remarkable ability to regenerate following myotrauma. Because adult myofibers are terminally differentiated, the regeneration of skeletal muscle is largely dependent on a small population of resident cells termed satellite cells. Although this population of cells was identified 40 years ago, little is known regarding the molecular phenotype or regulation of the satellite cell. The use of cell culture techniques and transgenic animal models has improved our understanding of this unique cell population; however, the capacity and potential of these cells remain ill-defined. This review will highlight the origin and unique markers of the satellite cell population, the regulation by growth factors, and the response to physiological and pathological stimuli. We conclude by highlighting the potential therapeutic uses of satellite cells and identifying future research goals for the study of satellite cell biology.

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          Author and article information

          Journal
          J Appl Physiol (1985)
          Journal of applied physiology (Bethesda, Md. : 1985)
          American Physiological Society
          8750-7587
          0161-7567
          Aug 2001
          : 91
          : 2
          Affiliations
          [1 ] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
          Article
          10.1152/jappl.2001.91.2.534
          11457764
          fea78456-3546-4855-97f8-e8109b473561
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