Objective: The goal of the study was to compare the quality of life of patients with multiple sclerosis (MS) in Eastern Slovakia Region from the point of view of support MS organizations. Design: comparative study, cross-sectional study. Methods and participants: The sample of research consisted of 121 patients with multiple sclerosis (53 respondents who attended the self-help organization and 68 who did not attend the organization). We used to evaluate the standardized questionnaire WHOQOL-BREF. The results indicate that social intervention have a positive impact on the quality of life of physical, mental and social health. Conclusion: Clinical observation of the results of studies present that social support provided to clients with chronical disease can be very useful.