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      Detection and quantitation in rat tissues of the superparamagnetic magnetic resonance contrast agent dextran magnetite as demonstrated by electron spin resonance spectroscopy.

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          Abstract

          The compound studies in this article is a superparamagnetic macromolecular complex of magnetite cores coated with hydrophilic dextran, which is under active investigation as a contrast agent for magnetic resonance imaging (MRI) in liver and spleen. The biodistribution of paramagnetic compounds is problematic and is usually studied by histochemical reactions or by radiolabeling the compound under study. The purpose of this article is to show how electron spin resonance (ESR) spectroscopy detects dextran magnetite (DM) particles in tissues.

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          Author and article information

          Journal
          Invest Radiol
          Investigative radiology
          0020-9996
          0020-9996
          Jun 1992
          : 27
          : 6
          Affiliations
          [1 ] Istituto di Patologia Generale, Modena, Italy.
          Article
          1376725

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