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      The Status of the Corticotropin Releasing Factor (CRF)

      ,

      Neuroendocrinology

      S. Karger AG

      CRF, ACTH-Release, Stress, Vasopressin, Hypothalamus, Anterior pituitary, Adrenal cortex

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          Abstract

          Early in the history of studies on the release of ACTH by stress there were indications that ACTH might be released by multiple factors. But the neurohumoral theory, as formulated by G. W. Harris, suggested that every hypophysial hormone had its unique hypothalamic controlling agent and a search for the unique ACTH-releasing hormone went on for about 20 years. This review reexamines the case for multiple releasers of ACTH.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1977
          1977
          25 March 2008
          : 24
          : 5-6
          : 359-375
          Affiliations
          Department of Biochemistry, Medical College of Ohio, Toledo, Ohio, and V. A. Hospital and Tulane University School of Medicine, New Orleans, La.
          Article
          122723 Neuroendocrinology 1977;24:359–375
          10.1159/000122723
          347327
          © 1977 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 17
          Categories
          Current Review

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