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      Matricellular protein SPARC/osteonectin expression is regulated by DNA methylation in its core promoter region.

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          Abstract

          SPARC/osteonectin is an evolutionarily conserved matricellular protein that modulates cell-matrix interaction and cell function. In all vertebrates, SPARC is dynamically expressed during embryogenesis. However, the precise function of SPARC and the regulatory elements required for its expression in particular during early embryogenesis are largely unknown.

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          Author and article information

          Journal
          Dev Dyn
          Developmental dynamics : an official publication of the American Association of Anatomists
          Wiley
          1097-0177
          1058-8388
          May 2015
          : 244
          : 5
          Affiliations
          [1 ] Aquatic Molecular Pathobiology Lab, Instituto de Investigaciones Marinas (IIM-CSIC), Vigo, Spain.
          Article
          10.1002/dvdy.24267
          25728805
          fee3fdab-ddb8-4bac-a280-bed49ded5e24
          © 2015 Wiley Periodicals, Inc.

          CpG island,methylation,osteonectin,sparc,transcriptional regulation,zebrafish

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