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      Factors Associated With Alcohol Use Disorder Among People Living With HIV/AIDS Attending Art Clinic, Mizan Tep University Teaching Hospital, South West Ethiopia

      research-article
      1
      HIV/AIDS (Auckland, N.Z.)
      Dove
      magnitude, alcohol use disorder, factors

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          Abstract

          Introduction

          Alcohol use is a major public health concern in global settings. It is very common among people living with HIV/AIDS, leading to physical and mental complications.

          Objective

          To assess the magnitude of alcohol use and factors among HIV/AIDS positive adults visiting ART clinic at Mizan Tep University Teaching Hospital (MTUTH), Southern Ethiopia from October 2017 to December 2017.

          Methods

          A facility based cross-sectional study was conducted with a sample of 332 HIV positive adults who came to ART clinic at MTUTH using systemic random sampling technique. Data were entered into EPidata 3.1 version and then analyzed by SPSS version 20. Binary logistic regressions have been used to identify the association between an independent variable with the dependent variable.

          Result

          A total of 332 participants were enrolled in the study with the prevalence of alcohol use disorder (AUD) of 18.4%. Factors associated with alcohol use disorder were sex AOR=3.48 (95% CI: 1.27, 9.59), cigarette smoking AOR=5.12 (95% CI: 4.02, 8.61), “khat” chewing AOR=3.23 (95% CI: 2.06.6.89), and CD4 count of 0–200 AOR = 19.49 (95% CI: 1.74, 218.4).

          Conclusion

          The prevalence of alcohol use disorder was high. It is independently associated with male patients, cigarette/tobacco smokers, khat chewers, and low CD4 count.

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          Most cited references7

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          Adding fuel to the fire: alcohol's effect on the HIV epidemic in Sub-Saharan Africa.

          Alcohol consumption adds fuel to the HIV epidemic in sub-Saharan Africa (SSA). SSA has the highest prevalence of HIV infection and heavy episodic drinking in the world. Alcohol consumption is associated with behaviors such as unprotected sex and poor medication adherence, and biological factors such as increased susceptibility to infection, comorbid conditions, and infectiousness, which may synergistically increase HIV acquisition and onward transmission. Few interventions to decrease alcohol consumption and alcohol-related sexual risk behaviors have been developed or implemented in SSA, and few HIV or health policies or services in SSA address alcohol consumption. Structural interventions, such as regulating the availability, price, and advertising of alcohol, are challenging to implement due to the preponderance of homemade alcohol and beverage industry resistance. This article reviews the current knowledge on how alcohol impacts the HIV epidemic in SSA, summarizes current interventions and policies, and identifies areas for increased research and development.
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            Is Open Access

            Influence of Alcohol Consumption on Adherence to and Toxicity of Antiretroviral Therapy and Survival

            Antiretroviral therapy (ART) has substantially altered the fate of HIV-infected people, transforming the infection from an invariably fatal disease to a chronic condition manageable by pharmacotherapy. However, in order for ART to be effective, patients must adhere strictly to an often-demanding treatment regimen. Alcohol consumption may impact survival of HIV-infected patients through a variety of pathways. Some of these are not related to the effectiveness of ART (e.g., alcohol-induced immunosuppression that exacerbates the HIV-related immunosuppression, increased hepatotoxicity, and increased mortality from non–HIV-related causes). However, some pathways mediating alcohol’s negative effect on survival are related to ART effectiveness. In particular, alcohol consumption may reduce adherence to ART, leading to decreased ART effectiveness and, ultimately, increased HIV-related mortality. Both clinical data and computer simulations have yielded information about the impact of alcohol consumption on medication adherence in both HIV-infected and noninfected patients. The findings suggest that alcohol-related nonadherence may account for a substantial amount of preventable mortality among HIV-infected patients. These findings may have clinical implications with respect to optimal treatment for HIV-infected patients who also consume alcohol.
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              Screening for hazardous alcohol use and depressive symptomatology among HIV-infected patients in Nigeria: prevalence, predictors, and association with adherence.

              Scores from the Alcohol Use Disorders Identification Test (AUDIT) and the Center for Epidemiological Studies Depression Scale (CES-D) administered to both antiretroviral therapy (ART)-experienced and -naive adults in HIV care in Nigeria were evaluated for association with participant characteristics and ART adherence measured by pharmacy records. Participants included 222 ART-experienced and 177 ART-naive adults, of whom 47 (12%) had AUDIT >/=8, 29 (7%) an AUDIT >/=10, 52 (13%) a CES-D >/=16, and 25 (6%) a CES-D >/=21. An elevated AUDIT score was more frequent among ART-naive and men, while disclosure of HIV status to others was associated with lower scores. An elevated CES-D score was more frequent among ART-naive and those with lower educational level, while disclosure of HIV status and choosing to be interviewed in English rather than Hausa was associated with lower scores. An elevated CES-D score was associated with poor adherence.
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                Author and article information

                Journal
                HIV AIDS (Auckl)
                HIV AIDS (Auckl)
                HIV
                hiv
                HIV/AIDS (Auckland, N.Z.)
                Dove
                1179-1373
                10 October 2019
                2019
                : 11
                : 239-245
                Affiliations
                [1 ]School of Nursing, College of Medicine and Health Science, Hawassa University , Hawassa, Ethiopia
                Author notes
                Correspondence: Bereket Beyene Gebre School of Nursing, College of Medicine and Health Science, Hawassa University , Hawassa, Ethiopia Email bereket2007beyene@gmail.com
                Article
                220211
                10.2147/HIV.S220211
                6791487
                31632156
                fee5034b-9a4c-4753-9007-cc8827565f38
                © 2019 Gebre.

                This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

                History
                : 20 June 2019
                : 10 September 2019
                Page count
                Tables: 2, References: 14, Pages: 7
                Categories
                Original Research

                Infectious disease & Microbiology
                magnitude,alcohol use disorder,factors
                Infectious disease & Microbiology
                magnitude, alcohol use disorder, factors

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