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      Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies.

      1 ,
      Psychopharmacology
      Springer Science and Business Media LLC

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          Abstract

          Repeated exposure to many drugs of abuse results in a progressive and enduring enhancement in the motor stimulant effect elicited by a subsequent drug challenge. This phenomenon, termed behavioral sensitization, is thought to underlie certain aspects of drug addiction. Behavioral sensitization is the consequence of drug-induced neuroadaptive changes in a circuit involving dopaminergic and glutamatergic interconnections between the ventral tegmental area, nucleus accumbens, prefrontal cortex and amygdala.

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          Author and article information

          Journal
          Psychopharmacology (Berl)
          Psychopharmacology
          Springer Science and Business Media LLC
          0033-3158
          0033-3158
          Aug 2000
          : 151
          : 2-3
          Affiliations
          [1 ] Research Institute Neurosciences Vrije Universiteit, Department of Pharmacology, Medical Faculty, Free University, Amsterdam, The Netherlands. ljmj.vanderschuren.pharm@med.vu.nl
          Article
          10.1007/s002130000493
          10972458
          fefc0dce-e32a-43d6-90e5-287c0840bd56
          History

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